2-Amino-5-cyanopyridine → HCID 58869822, compound

Participants

Reaction Steps

The product of Example 11, Part D (113 mg, 0.34 mmol) and 2-amino-5-cyanopyridine (41 mg, 0.34 mmol) were converted to the title compound in a manner analogous to the method described in Example 27 (61 mg, 41%). 1H NMR (400 MHz, CDCl3) δ 8.48 (broad s, 1H); 8.24 (d, J=8.6 Hz, 1H), 7.92 (d, J=8.7 Hz, 1H), 7.82 (broad s, 1H), 7.70 (d, J=7.6 Hz, 1H); 7.49-7.45 (m, 1H), 7.33 (m, 2H), 7.23 (t, J=8.6 Hz, 1H); 7.04 (t, J=8.5 Hz, 2H); 5.24 (d, J=15 Hz, 1H), 4.72 (m, 1H), 4.28 (d, J=15 Hz, 1H), 2.61-2.56 (m, 1H); 2.53-2.46 (m, 1H); 2.00-1.95 (m, 2H). MS: m/z (MH+) 433.

Provenance & Evidence