6-{3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionylamino}-nicotinic acid → HCID 58869834, compound

Participants

Reaction Steps

The product of Example 11, Part D (0.175 g, 0.529 mmol) and 5-Methanesulfonyl-pyridin-2-ylamine (91 mg, 0.529 mmol) were converted to the title compound in a manner analogous to the method described in Example 27 (159 mg, 62%). 1H NMR (400 MHz, CDCl3) d 8.74 (s, 1H); 8.30 (d, J=8.8 Hz, 1H), 8.18 (d, J=8.8 Hz, 1H), 8.09 (broad s, 1H), 7.69 (d, J=7 Hz, 1H); 7.49-7.44 (m, 1H), 7.33-7.30 (m, 2H), 7.23 (t, J=8.8 Hz, 1H); 7.04 (t, J=8.6 Hz, 2H); 5.25 (d, J=15 Hz, 1H), 4.73 (m, 1H), 4.28 (d, J=15 Hz, 1H), 3.18 (s, 3H); 2.61-2.59 (m, 1H); 2.53-2.50 (m, 1H); 2.04-1.97 (m, 2H). MS: m/z (MH+) 486.

Provenance & Evidence