(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941385, compound

HRID 2402319Notes

Reaction equation

HRID 2402319 reaction equation
Br[C:2]1[C:3]([F:21])=[C:4]([C:8]([NH:10][C:11]2[O:12][C:13]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)=[N:14][N:15]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH3:23]>>[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([NH:10][C:11]4[O:12][C:13]([C:16]5[O:17][CH:18]=[CH:19][CH:20]=5)=[N:14][N:15]=4)=[O:9])[C:3]=3[F:21])=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH3:23]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941438HCID 70941438, compound

Product 1

HCID 70941385HCID 70941385, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-2-fluoro-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]benzenecarboxamide prepared in Reference Example 5 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 5 instead of compound

Sources & evidence

ORD record
ord-0c0a52622bba4f5c9ce8121782527ac9
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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