(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941174, compound

HRID 2402320Notes

Reaction equation

HRID 2402320 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:9]([NH:11][C:12]2[O:13][C:14]([C:17]3[O:18][CH:19]=[CH:20][CH:21]=3)=[N:15][N:16]=2)=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH3:23]>>[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:2]3[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([C:9]([NH:11][C:12]4[O:13][C:14]([C:17]5[O:18][CH:19]=[CH:20][CH:21]=5)=[N:15][N:16]=4)=[O:10])[CH:3]=3)=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH3:23]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941545HCID 70941545, compound

Product 1

HCID 70941174HCID 70941174, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-5-fluoro-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]benzenecarboxamide prepared in Reference Example 6 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 6 instead of compound

Sources & evidence

ORD record
ord-88ef881fea094e8d895a0ee2491ee466
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

Loading…