1,1'-Biphenyl-4-yl-boronic acid → HCID 70941572, compound

HRID 2402323Notes

Reaction equation

HRID 2402323 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]([NH:10][C:11]2[O:12][C:13]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)=[N:14][N:15]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[C:21]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1>>[C:21]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:26]=[CH:25][C:24]([C:2]2[CH:3]=[C:4]([C:8]([NH:10][C:11]3[O:12][C:13]([C:16]4[O:17][CH:18]=[CH:19][CH:20]=4)=[N:14][N:15]=3)=[O:9])[CH:5]=[N:6][CH:7]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 1512531,1'-Biphenyl-4-yl-boronic acidHCID 70941339HCID 70941339, compound

Product 1

HCID 70941572HCID 70941572, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 5-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3-pyridinecarboxamide prepared in Reference Example 8 instead of compound Ia-50 and using commercially available 4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 8 instead of compound

Sources & evidence

ORD record
ord-e8a8c249a8214feda7a9ddd03f0c972a
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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