(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941433, compound

HRID 2402324Notes

Reaction equation

HRID 2402324 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]([NH:10][C:11]2[O:12][C:13]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)=[N:14][N:15]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[CH2:21]([C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=2)=[CH:25][CH:24]=1)[CH3:22]>>[CH2:21]([C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][C:32]([C:2]3[CH:3]=[C:4]([C:8]([NH:10][C:11]4[O:12][C:13]([C:16]5[O:17][CH:18]=[CH:19][CH:20]=5)=[N:14][N:15]=4)=[O:9])[CH:5]=[N:6][CH:7]=3)=[CH:31][CH:30]=2)=[CH:25][CH:24]=1)[CH3:22]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941339HCID 70941339, compound

Product 1

HCID 70941433HCID 70941433, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 5-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3-pyridinecarboxamide prepared in Reference Example 8 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 8 instead of compound

Sources & evidence

ORD record
ord-40fe55a1371248aaaad25ca6d0f2afa0
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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