(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941288, compound

HRID 2402325Notes

Reaction equation

HRID 2402325 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:9]([NH:11][C:12]2[O:13][C:14]([C:17]3[O:18][CH:19]=[CH:20][CH:21]=3)=[N:15][N:16]=2)=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH3:23]>>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]([NH:11][C:12]2[O:13][C:14]([C:17]3[O:18][CH:19]=[CH:20][CH:21]=3)=[N:15][N:16]=2)=[O:10])[CH:3]=[C:2]([C:33]2[CH:34]=[CH:35][C:30]([C:27]3[CH:26]=[CH:25][C:24]([CH2:22][CH3:23])=[CH:29][CH:28]=3)=[CH:31][CH:32]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941202HCID 70941202, compound

Product 1

HCID 70941288HCID 70941288, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-5-chloro-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]benzenecarboxamide prepared in Reference Example 36 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 36 instead of compound

Sources & evidence

ORD record
ord-a5bc0306cd8347febaa784aff16b7b22
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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