(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941214, compound

HRID 2402326Notes

Reaction equation

HRID 2402326 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:11]([NH:13][C:14]2[O:15][C:16]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[N:17][N:18]=2)=[O:12])[CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.[CH2:24]([C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=2)=[CH:28][CH:27]=1)[CH3:25]>>[CH2:24]([C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35]([C:2]3[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([C:11]([NH:13][C:14]4[O:15][C:16]([C:19]5[O:20][CH:21]=[CH:22][CH:23]=5)=[N:17][N:18]=4)=[O:12])[CH:3]=3)=[CH:34][CH:33]=2)=[CH:28][CH:27]=1)[CH3:25]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941492HCID 70941492, compound

Product 1

HCID 70941214HCID 70941214, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-5-nitrobenzenecarboxamide prepared in Reference Example 37 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 37 instead of compound

Sources & evidence

ORD record
ord-2df7494eb57a4016b63a06f8b1e96fee
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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