(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941259, compound

HRID 2402327Notes

Reaction equation

HRID 2402327 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7](Br)[CH:8]=[C:9]([C:11]([NH:13][C:14]2[O:15][C:16]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[N:17][N:18]=2)=[O:12])[CH:10]=1)(=[O:3])[CH3:2].[CH2:25]([C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=2)=[CH:29][CH:28]=1)[CH3:26]>>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:11]([NH:13][C:14]2[O:15][C:16]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[N:17][N:18]=2)=[O:12])[CH:8]=[C:7]([C:36]2[CH:37]=[CH:38][C:33]([C:30]3[CH:29]=[CH:28][C:27]([CH2:25][CH3:26])=[CH:32][CH:31]=3)=[CH:34][CH:35]=2)[CH:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941484HCID 70941484, compound

Product 1

HCID 70941259HCID 70941259, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 5-acetylamino-3-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]benzenecarboxamide prepared in Reference Example 38 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 38 instead of compound

Sources & evidence

ORD record
ord-06207126113c4d0897ffcb95b23970af
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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