(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941383, compound

HRID 2402328Notes

Reaction equation

HRID 2402328 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:12]([NH:14][C:15]2[O:16][C:17]([C:20]3[O:21][CH:22]=[CH:23][CH:24]=3)=[N:18][N:19]=2)=[O:13])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:25]([C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=2)=[CH:29][CH:28]=1)[CH3:26]>>[CH2:25]([C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36]([C:2]3[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]([NH:14][C:15]4[O:16][C:17]([C:20]5[O:21][CH:22]=[CH:23][CH:24]=5)=[N:18][N:19]=4)=[O:13])[CH:3]=3)=[CH:35][CH:34]=2)=[CH:29][CH:28]=1)[CH3:26]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941280HCID 70941280, compound

Product 1

HCID 70941383HCID 70941383, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-5-trifluoromethylbenzenecarboxamide prepared in Reference Example 39 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 39 instead of compound

Sources & evidence

ORD record
ord-e4209bfde5af4366a6e4023b8ac597b1
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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