(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941367, compound

HRID 2402329Notes

Reaction equation

HRID 2402329 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:13]([NH:15][C:16]2[O:17][C:18]([C:21]3[O:22][CH:23]=[CH:24][CH:25]=3)=[N:19][N:20]=2)=[O:14])[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.[CH2:26]([C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=2)=[CH:30][CH:29]=1)[CH3:27]>>[CH2:26]([C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:39]=[CH:38][C:37]([C:2]3[CH:7]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[C:4]([C:13]([NH:15][C:16]4[O:17][C:18]([C:21]5[O:22][CH:23]=[CH:24][CH:25]=5)=[N:19][N:20]=4)=[O:14])[CH:3]=3)=[CH:36][CH:35]=2)=[CH:30][CH:29]=1)[CH3:27]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941328HCID 70941328, compound

Product 1

HCID 70941367HCID 70941367, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-5-trifluoromethoxybenzenecarboxamide prepared in Reference Example 40 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 40 instead of compound

Sources & evidence

ORD record
ord-50fe24bb58b6443e87d0478ba2325bb8
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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