(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 70941236, compound

HRID 2402330Notes

Reaction equation

HRID 2402330 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:10]([NH:12][C:13]2[O:14][C:15]([C:18]3[O:19][CH:20]=[CH:21][CH:22]=3)=[N:16][N:17]=2)=[O:11])[CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=2)=[CH:27][CH:26]=1)[CH3:24]>>[C:8]([C:6]1[CH:5]=[C:4]([C:10]([NH:12][C:13]2[O:14][C:15]([C:18]3[O:19][CH:20]=[CH:21][CH:22]=3)=[N:16][N:17]=2)=[O:11])[CH:3]=[C:2]([C:34]2[CH:35]=[CH:36][C:31]([C:28]3[CH:27]=[CH:26][C:25]([CH2:23][CH3:24])=[CH:30][CH:29]=3)=[CH:32][CH:33]=2)[CH:7]=1)#[N:9]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941706HCID 70941706, compound

Product 1

HCID 70941236HCID 70941236, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 3-bromo-5-cyano-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]benzenecarboxamide prepared in Reference Example 41 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 41 instead of compound

Sources & evidence

ORD record
ord-dd1cbf6c9f734deebad1537625160863
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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