4-Cyanophenylboronic acid → HCID 70941390, compound

HRID 2402334Notes

Reaction equation

HRID 2402334 reaction equation
Br[C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[O:11][C:12]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[N:13][N:14]=2)=[O:8])=[CH:4][CH:3]=1.O1C=CC=C1C1OC([NH:30][C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35](I)[CH:34]=2)=O)=NN=1.C(C1C=CC(B(O)O)=CC=1)#N>>[C:31]([C:33]1[CH:38]=[CH:37][C:36]([C:2]2[S:6][C:5]([C:7]([NH:9][C:10]3[O:11][C:12]([C:15]4[O:16][CH:17]=[CH:18][CH:19]=4)=[N:13][N:14]=3)=[O:8])=[CH:4][CH:3]=2)=[CH:35][CH:34]=1)#[N:30]

Participants

4

Reactant 3

HCID 27343264-Cyanophenylboronic acidHCID 3611482HCID 3611482, compoundHCID 70941647HCID 70941647, compound

Product 1

HCID 70941390HCID 70941390, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 5-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-2-thiophenecarboxamide prepared in Reference Example 4 instead of N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3-iodobenzenecarboxamide and using commercially available 4-cyanophenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Sources & evidence

ORD record
ord-3dfe3929a5b74188b5ddf2a684bba64c
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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