1,1'-Biphenyl-4-yl-boronic acid → HCID 70941315, compound

HRID 2402335Notes

Reaction equation

HRID 2402335 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:7]([NH:9][C:10]2[O:11][C:12]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[N:13][N:14]=2)=[O:8])[S:5][CH:6]=1.[C:20]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[C:20]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:25]=[CH:24][C:23]([C:2]2[CH:3]=[C:4]([C:7]([NH:9][C:10]3[O:11][C:12]([C:15]4[O:16][CH:17]=[CH:18][CH:19]=4)=[N:13][N:14]=3)=[O:8])[S:5][CH:6]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 1512531,1'-Biphenyl-4-yl-boronic acidHCID 70941306HCID 70941306, compound

Product 1

HCID 70941315HCID 70941315, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 4-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-2-thiophenecarboxamide prepared in Reference Example 12 instead of compound Ia-50 and using commercially available 4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 12 instead of compound

Sources & evidence

ORD record
ord-5997aac7812d4a8f96d8f92e8880674d
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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