(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acid → HCID 53327150, compound

HRID 2402336Notes

Reaction equation

HRID 2402336 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:7]([NH:9][C:10]2[O:11][C:12]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[N:13][N:14]=2)=[O:8])[S:5][CH:6]=1.[CH2:20]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH3:21]>>[CH2:20]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:2]3[CH:3]=[C:4]([C:7]([NH:9][C:10]4[O:11][C:12]([C:15]5[O:16][CH:17]=[CH:18][CH:19]=5)=[N:13][N:14]=4)=[O:8])[S:5][CH:6]=3)=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH3:21]

Participants

3

Reactant 2

HCID 45789738(4'-Ethyl[1,1'-biphenyl]-4-yl)boronic acidHCID 70941306HCID 70941306, compound

Product 1

HCID 53327150HCID 53327150, compound

Procedure

The title compound was synthesized in accordance with the synthesis method of compound Ia-50, using 4-bromo-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-2-thiophenecarboxamide prepared in Reference Example 12 instead of compound Ia-50 and using commercially available 4′-ethyl-4-biphenylboronic acid instead of 1-methyl-5-indoleboronic acid pinacol ester.

Workup

  1. customprepared in Reference Example 12 instead of compound

Sources & evidence

ORD record
ord-cd6e6060ed1e45db91dc4c93c6d52217
Source dataset
uspto-grants-2014_08
Patent number
US08796320B2

Reaction notes

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