反应详情

温度

5 °C

Under argon and at −10° C., 20 g (110.7 mmol) of (4-chlorophenyl)(cyclopropyl)methanone were added slowly to 60 ml of concentrated nitric acid. The reaction mixture was then slowly warmed to 5° C. and stirred at this temperature for 6 h. Carefully, the reaction solution was then added with stirring to about 100 ml of ice-water. This resulted in the precipitation of a white solid which was filtered off with suction and washed repeatedly with water. The solid obtained in this manner was then dried under high vacuum. This gave 24.3 g (97% of theory) of the desired product.

1. additionCarefully, the reaction solution was then added
2. customThis resulted in the precipitation of a white solid which
3. filtrationwas filtered off with suction
4. washwashed repeatedly with water
5. customThe solid obtained in this manner
6. customwas then dried under high vacuum