Hydrochloric Acid → Methyl 4-Iodophenylacetate

Participants

Reaction Steps

A 4M solution of HCl in dioxane (50 mL) was added to 2-(4-iodophenyl)acetic acid (10 g, 38.2 mmol) in MeOH (100 mL) and the reaction stirred overnight. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography eluting with 0-30% EtOAc in hexanes to afford methyl 2-(4-iodophenyl)acetate in 10.42 g (99%). LRMS: 276.0 (calc) 277.1 (found)(MH+)+.

Provenance & Evidence