Acetone → HCID 131731739, compound

HRID 2402533Notes

Reaction equation

HRID 2402533 reaction equation
[ClH:1].[OH:2][CH:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[NH2:5].CC(C)=O.O.CC(C)=O>O>[OH2:2].[ClH:1].[OH:2][C@H:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[NH2:5]

Participants

5

Reactant 3

HCID 180Acetone3×HCID 18366337Propan-2-one--water (1/1)HCID 129629239HCID 129629239, compound

Product 1

HCID 131731739HCID 131731739, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

Suitably, the method may further comprise the preliminary steps of: dissolving the anomeric mixture of lactosamine hydrochloride in water; and adding the solution to a much larger volume of acetone, such as a tenfold volume of acetone compared with the volume of the aqueous solution, to cause precipitation of a white powder, which powder is then used as the anomeric mixture in preparing the solution comprising the anomeric mixture, water and at least one water miscible organic solvent. This preliminary step forms an acetone adduct of the anomeric mixture that is insoluble in this water/acetone mixture, and so precipitates as a white powder leaving other impurities in solution.

Workup

  1. dissolutiondissolving
  2. customprecipitation of a white powder, which powder
  3. customis then used as the anomeric mixture in preparing the solution
  4. customso precipitates as a white powder
  5. customleaving other impurities in solution

Sources & evidence

ORD record
ord-1fe7311bda644f96b615c3591608c653
Source dataset
uspto-grants-2014_08
Patent number
US08796434B2

Reaction notes

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