HCID 58031819, compound → HCID 56602328, compound

Participants

Reaction Steps

A solution of 171 mg of 2-(1-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}but-2-ynyl)malonic acid in 5 ml of dioxane was boiled at 120° C. for 17 h. The reaction mixture was concentrated and separated by means of preparative HPLC (Merck Hibar Purospher Star RP-18e 10 μm 25×250 mm; A: H2O+0.05% TFA; B: ACN+0.05% TFA; flow rate: 50 ml/min; in 15 minutes 10% B→90% B). The product fractions were freeze-dried to obtain 85 mg (54%) of 3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid. C22H21BrClNO4 (478.77), LCMS (ESI-pos): 478/480/482 (M+H+).

Provenance & Evidence