HCID 178475034, compound → HCID 178511696, compound

Participants

Reaction Steps

680 mg (1.74 mmol) of N-[4-(1-benzyloxy-isoquinolin-6-yloxy)-cyclohexyl]-acetamide (19) were heated in 2 N HCl in an autoclave at 120° C. until complete conversion is achieved. The solvent is removed in vacuo and the residue is purified by preparative HPLC. The product fractions were evaporated and dissolved in 2 N HCl. After lyophilisation 182 mg of the title compound could be obtained as hydrochloride. Rt=0.97 min (Method B). Detected mass: 259.2 (M+H+).

Provenance & Evidence