Ethylmorpholine → HCID 58031814, compound

Participants

Reaction Steps

A solution of 150 mg (0.56 mmol) of ethyl 3-(4-aminophenyl)hex-4-ynoate, 193 mg (1.68 mmol) of N-ethylmorpholine, 103 mg (0.67 mmol) of HOBt hydrate and 104 mg (0.67 mmol) of EDAC in 3 ml of DMF was added to a solution of 160 mg (0.62 mmol) of 2-(5-bromo-2-methylphenoxy)propionic acid in 2 ml of DMF. After 3 days at room temperature, the reaction mixture was diluted with sodium chloride solution and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure. This gave ethyl 3-{4-[2-(5-bromo-2-methylphenoxy)propionylamino]phenyl}hex-4-ynoate.

Provenance & Evidence