Chloroform → HCID 67468253, compound

HRID 2402735Notes

Reaction equation

HRID 2402735 reaction equation
[Br:1][C:2]1[CH:3]=C[C:5]2[NH:6][C:7]3[C:12]([S:13][C:14]=2[CH:15]=1)=[CH:11][C:10]([Br:16])=[CH:9][CH:8]=3.S(Cl)([Cl:20])(=O)=O.[CH:22]([Cl:25])(Cl)Cl>>[Br:1][C:2]1[CH:3]=[C:22]([Cl:25])[C:5]2[NH:6][C:7]3[C:12]([S:13][C:14]=2[CH:15]=1)=[CH:11][C:10]([Br:16])=[CH:9][C:8]=3[Cl:20]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 24648Sulfuryl chlorideHCID 35471153,7-dibromo-10H-phenothiazine

Product 1

HCID 67468253HCID 67468253, compound

Procedure

The 3,7-dibromophenothiazine (6.25 g, 17.5 mmol) was dissolved in 200 mL of chloroform (CHCl3). Sulfuryl chloride (SO2Cl2, 3.13 mL, 38.5 mmol) was added dropwise over 15 min. The dark mixture was stirred at RT for 36 h. The mixture was then filtered and the solid washed with CHCl3. The solid was collected and stirred in Et2O and the resulting green solid was filtered off and dried under vacuum to give a quantitative yield of the desired product.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe solid washed with CHCl3
  3. customThe solid was collected
  4. stirringstirred in Et2O
  5. filtrationthe resulting green solid was filtered off
  6. customdried under vacuum

Sources & evidence

ORD record
ord-39206c3cbce24224b6561a5c246f5909
Source dataset
uspto-grants-2014_08
Patent number
US08796448B1

Reaction notes

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