Acetic Acid → HCID 86659845, compound

Participants

Reaction Steps

Sulfuric acid (1.437 mL, 27.0 mmol) was added to a solution of (3aS,6aS)-2-benzyl-4-methyleneoctahydrocyclopenta[c]pyrrole (0.575 g, 2.70 mmol, Example 1) in acetic acid (1.466 mL, 25.6 mmol) and benzonitrile (1.390 mL, 13.48 mmol) at 0° C. The reaction was stirred at room temperature overnight. The reaction mixture was quenched with ice, extracted with dichloromethane, and then purified by silica gel chromatography using 1-10% methanol (2 N ammonia)/dichloromethane as eluent to give the title compounds.

Provenance & Evidence