Hydrochloric Acid → 2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride

HRID 2402769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2402769
[N+:1]([CH2:4][CH:5]([NH:16]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)([O-:3])=[O:2].[ClH:24]>O1CCOCC1>[ClH:24].[N+:1]([CH2:4][CH:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=1)[NH2:16])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59536870tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Produkt 1

HCID 686464472-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Of the compound from Example 12A, 340 mg (1.02 mmol) were admixed at RT with 6.8 ml of a 4N solution of hydrogen chloride in dioxane, and stirred for 1 h. The reaction mixture was concentrated under reduced pressure and dried in an HV. This gave 274 mg (99% of theory) of the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried in an HV

Quellen und Nachweise

ORD-Eintrag
ord-d8ffa92b2c4b48bbb9bc6d7310880b63
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796324B2

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