(Trifluoromethyl)trimethylsilane → HCID 59536939, compound

Participants

Reaction Conditions

Reaction Steps

Of the compound from Example 97A, 300 mg (0.78 mmol) were dissolved in 5 ml of THF, cooled to 0° C., and admixed with 183 μl (1.17 mmol) of (trifluoromethyl)trimethylsilane and then with 39 μl (39 μmol) of a 1M solution of tetra-n-butylammonium fluoride in THF. The cooling bath was removed and the mixture was stirred at RT overnight. Following addition of 2 ml of 1N hydrochloric acid, it was stirred for a further 30 min. The THF was removed on a rotary evaporator and the product was purified by preparative chromatography (Method 10). This gave 168 mg (47% of theory) of the title compound as a diastereomer mixture (ratio about 3:2)

Provenance & Evidence