Acetonitrile → HCID 86671129, compound

Participants

Reaction Steps

A solution of 272 mg (0.89 mmol) of the compound from Example 101A and 171 μl (0.98 mmol) of N,N-diisopropylethylamine in 3 ml of acetonitrile was admixed dropwise with a solution of 106 μl (0.98 mmol) of 2-bromoethyl chloroformate in 2 ml of acetonitrile. For work-up, after 10 minutes, ethyl acetate and saturated aqueous sodium hydrogen carbonate solution were added. The organic phase was separated, washed again with saturated aqueous sodium hydrogen carbonate solution, dried over sodium sulphate and freed from the volatile constituents on a rotary evaporator. Drying of the residue in an HV gave 352 mg (82% of theory) of the title compound.

Provenance & Evidence