反应详情

A quantity of 12.53 g (90.7 mmol) of potassium carbonate was heated through in an HV and then cooled under an argon atmosphere. Quantities of 140 ml of anhydrous THF and 5.77 g (15.1 mmol) of the compound from Example 110A were added and the mixture was stirred under an argon atmosphere at reflux temperature for 16 h. After cooling to RT, the reaction mixture was filtered over celite. The solid was washed with a little THF. The entire filtrate was freed from the solvent on a rotary evaporator. The oily residue was dried in an HV. This gave 3.55 g (98% of theory) of the title compound.

1. temperaturecooled under an argon atmosphere
2. temperatureat reflux temperature for 16 h
3. filtrationthe reaction mixture was filtered over celite
4. washThe solid was washed with a little THF
5. customThe entire filtrate was freed from the solvent on a rotary evaporator
6. customThe oily residue was dried in an HV