Ethyl chloroformate → HCID 59536793, compound

HRID 2402801Notes

Reaction equation

HRID 2402801 reaction equation
[NH2:1][CH2:2][CH:3]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:5]=1[Cl:11].Cl[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:11][C:5]1[C:6]([Cl:10])=[CH:7][CH:8]=[CH:9][C:4]=1[CH:3]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17])[CH2:2][NH:1][C:21](=[O:22])[O:23][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 59536725HCID 59536725, compound

Product 1

HCID 59536793HCID 59536793, compound

Procedure

From 192 mg (629 μmol) of the compound from Example 40A and 72 μl (755 μmol) of ethyl chloroformate, in the same way as for Example 123A, 184 mg (78% of theory) of the title compound were prepared.

Sources & evidence

ORD record
ord-e41dd288bfe142f7a2ada45ba82decfa
Source dataset
uspto-grants-2014_08
Patent number
US08796324B2

Reaction notes

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