Hydrochloric Acid → HCID 59536869, compound

Participants

Reaction Conditions

Reaction Steps

At RT, 11.97 mg (0.28 mmol) of lithium chloride and 10.68 mg (0.28 mmol) of sodium borohydride were stirred in 0.25 ml of ethanol for 15 min. Then the mixture was cooled to 0° C. and a solution of 62 mg (about 0.09 mmol, purity 49%) of the compound from Example 131A in 0.25 ml of tetrahydrofuran was added dropwise. The mixture was stirred overnight at RT. For work-up, it was cooled with ice-water and adjusted to a pH of 2 using 1M hydrochloric acid. The reaction mixture was purified by preparative HPLC [Method 20]. The product fraction was freed from the solvent on a rotary evaporator and dried in an HV. This gave 56 mg (about 45% purity, 93% of theory) of the title compound.

Provenance & Evidence