Potassium cyanate → N-{2-(Carbamoylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

Participants

Reaction Conditions

Reaction Steps

Of the compound from Example 11, 266 mg (0.45 mmol) were introduced in 6 ml of methanol/water 1:1 and admixed with potassium cyanate (110 mg, 1.36 mmol) at RT. The mixture was heated at 40° C. for 90 min. Following complete reaction, the mixture was cooled to RT and purified completely by preparative HPLC (Method 10). Drying in an HV gave 232 mg (84% of theory) of the title compound.

Provenance & Evidence