3-Amino-1,1,1-trifluoro-3-phenylpropan-2-ol hydrochloride → HCID 59536896, compound

HRID 2402842Notes

Reaction equation

HRID 2402842 reaction equation
C(=O)(OCCC(N[C:15](=[O:37])[CH2:16][N:17]1[C:21](=[O:22])[N:20]([CH2:23][C@H:24]([OH:29])[C:25]([F:28])([F:27])[F:26])[C:19]([C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=2)=[N:18]1)C1C=CC=CC=1F)N.Cl.[NH2:40][CH:41]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)[CH:42]([OH:47])[C:43]([F:46])([F:45])[F:44]>>[Cl:36][C:33]1[CH:34]=[CH:35][C:30]([C:19]2[N:20]([CH2:23][C@H:24]([OH:29])[C:25]([F:27])([F:26])[F:28])[C:21](=[O:22])[N:17]([CH2:16][C:15]([NH:40][CH:41]([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH:42]([OH:47])[C:43]([F:44])([F:45])[F:46])=[O:37])[N:18]=2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 429337223-Amino-1,1,1-trifluoro-3-phenylpropan-2-ol hydrochlorideHCID 59536850HCID 59536850, compound

Product 1

HCID 59536896HCID 59536896, compound

Procedure

In the same way as for the compound from Example 93, 100 mg (0.27 mmol) of the compound from Example 8A and 73 mg (0.30 mmol) of 3-amino-1,1,1-trifluoro-3-phenylpropan-2-ol hydrochloride were reacted. This gave 102 mg (63% of theory) of the target compound as a diastereomer mixture.

Sources & evidence

ORD record
ord-ad1cb1fa5b024128b9ec55627952eb31
Source dataset
uspto-grants-2014_08
Patent number
US08796324B2

Reaction notes

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