1,2-Dichloroethane → Trifluoroacetic acid

Participants

Reaction Steps

TFA (3 mL, 38.9 mmol) was added to a stirred solution of carbamate J3b (316 mg, 0.470 mmol) in DCE (7 mL) and the reaction was stirred at rt for 1 h. The reaction mixture was concentrated under vacuum to yield a TFA salt of pyrrolidine J3c (360 mg) as a yellow solid.

Provenance & Evidence