Dichloromethane → N5-(3-chloro-4-methyl-5-sulfophenyl)-L-glutamine

Participants

Reaction Steps

1 mL of Methylene chloride and 1 mL of THF were added to 303 mg (1 mmol) of Boc-Glu-OtBu hydrochloride and 180 mg (1.1 mmol) of CDI. 221 mg of 5-Amino-3-chloro-2-methylbenzenesulfonic acid was added thereof and stirred at room temperature overnight. Purification was conducted in accordance with the purification process A to obtain a protected form of the intended compound. The obtained protected form was dissolved in 5 mL of a trifluoroacetic acid and stirred for 2 hours. After removing a solvent, purification was conducted in accordance with the purification process A to obtain a title compound.

Provenance & Evidence