(2,6-Dichlorophenyl)hydrazine monohydrochloride → HCID 89388322, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Example 159A (512 mg, 1.516 mmol) in 2,2,2-trifluoroethanol (15 mL) was added 2,6-dichlorophenylhydrazine hydrochloride (324 mg, 1.516 mmol). This mixture was heated in a sealed tube at 108° C. overnight. The mixture was partitioned between ethyl acetate and brine. The organic phase was concentrated, and the residue was purified by flash chromatography (15-50% ethyl acetate in hexane) to provide the title compound. MS (DCI/NH3) m/z 451 (M+H)+.

Provenance & Evidence