(2,6-Dichlorophenyl)hydrazine monohydrochloride → HCID 89388322, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Example 175A (512 mg, 1.52 mmol) in 2,2,2-trifluoroethanol (15 mL) was added 2,6-dichlorophenylhydrazine hydrochloride (324 mg, 1.516 mmol). The mixture was heated in a sealed tube at 108° C. overnight. After cooling, the mixture was partitioned between ethyl acetate and brine. The organic phase was concentrated. The residue was separated by flash chromatography (15-50% gradient ethyl acetate in hexane) to provide the title compound. MS (DCI/NH3) m/z 451 (M+H)+.

Provenance & Evidence