Potassium Carbonate → HCID 21871140, compound

Participants

Reaction Conditions

Reaction Steps

A flame dried 500 ml round-bottomed flask with a magnetic stir bar, was charged with 6-hydroxy-2-bromonaphthalene (8.0 g, 35.89 mMol), 3,4,5-trifluorophenyl boronic acid (6.9 g, 39.5 mMol), 75 mL toluene, 2M K2CO3 (80 mL), Bu4NBr (50 mg) and the mixture flushed with argon for 10 min. [Pd(PPh3)4] (0.5 g) was added and the mixture heated under argon at ˜85° C. overnight, with vigorous stirring. After cooling to room temperature, 50 mL water was added, extracted with 3×25 mL ethyl acetate, the organic extracts dried over MgSO4, and the crude product was then crystallized from a mixture of hexane and few drops of methanol. Yield: 8 g (87%).

Provenance & Evidence