Sodium Chloride → Amikacin

HRID 2403067Notes

Reaction equation

HRID 2403067 reaction equation
[CH2:1]1[C@@H:6]([NH:7][C:8]([C@@H:10]([OH:14])[CH2:11][CH2:12][NH2:13])=[O:9])[C@H:5]([O:15][C@H:16]2[O:21][C@H:20]([CH2:22][OH:23])[C@@H:19]([OH:24])[C@H:18]([NH2:25])[C@H:17]2[OH:26])[C@@H:4]([OH:27])[C@H:3]([O:28][C@H:29]2[O:34][C@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]2[OH:39])[C@H:2]1[NH2:40].OS(O)(=O)=O.[Na+].[Cl-].[OH-].[Na+].CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O.CC(CCC[C@H]([C@@H]1[C@]2(C)[C@H]([C@H]3[C@H](CC2)[C@]2(C)C(C[C@H](CC2)O)=CC3)CC1)C)C>C(O)C>[CH2:1]1[C@@H:6]([NH:7][C:8]([C@@H:10]([OH:14])[CH2:11][CH2:12][NH2:13])=[O:9])[C@H:5]([O:15][C@H:16]2[O:21][C@H:20]([CH2:22][OH:23])[C@@H:19]([OH:24])[C@H:18]([NH2:25])[C@H:17]2[OH:26])[C@@H:4]([OH:27])[C@H:3]([O:28][C@H:29]2[O:34][C@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]2[OH:39])[C@H:2]1[NH2:40]

Participants

7

Reactant 5

HCID 5234Sodium ChlorideHCID 5997CholesterolHCID 14798Sodium HydroxideHCID 452110Colfosceril PalmitateHCID 5458175Amikacin Sulfate Salt

Product 1

HCID 37768Amikacin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sample #1. Amikacin sulfate 1.72 kg was dissolved in 23 Liters saline solution (0.9% NaCl) and pH was adjusted to 6.5 by adding necessary amount NaOH. Lipids—98.2 g DPPC and 51.8 g Cholesterol were dissolved in 7 liters ethanol. Liposomes were formed by infusion of lipid solution into amikacin solution at a rate of ˜600 mL/min and under constant stirring. Resulting suspension was then washed to remove ethanol and un-entrapped amikacin by diafiltration using an Amersham Hollow Fiber cartridge 500 kD pore size. The suspension was concentrated to a final volume of ˜3.5 L.

Sources & evidence

ORD record
ord-05e090b808e74a179cbd44ac82b1d9b8
Source dataset
uspto-grants-2014_08
Patent number
US08802137B2

Reaction notes

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