HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240310Generated: October 27, 2026
Phosphorus oxychloride → 3-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile
https://huagongshe.com/reaction/240310
Participants
| Role | Name | HCID | Charge |
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| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178510555 | HCID 178510555 | — |
| Product | 3-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile | HCID 16065359 | 44% |
Reaction Steps
A suspension of 6 (671 mg, 3.0 mmol) in POCl3 (8.4 ml) was heated under stirring to 100° C. for 17 h. Excess of POCl3 was evaporated under reduced pressure and the crude was purified by flash chromatography on silica (CH2Cl2), affording 9 (320 mg, 44%) as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08648076B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-3ffab4eedf3a45cfb65973262b985db3 |
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| Source note | uspto-grants-2014_02 |
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