HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178471968, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile | HCID 292929 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178471968 | HCID 178471968 | 97.3% |
Reaction Steps
Ethylcyanoacetate (110 mg, 0.970 mmol) was dissolved, under inert atmosphere, in dry DMF (1 ml) and NaH (39 mg, 0.970 mmol) was added in one portion. After 30 min, a solution of 1 (150 mg, 0.646 mmol) in dry DMF (2 ml) was added dropwise. After 15 min MeOH was added and the solution stirred for 10 min. The solvents were evaporated and the crude purified by flash chromatography (EtOAc:MeOH 9:1) affording 22 as a dark red solid (200 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648076B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-acdda630ff26422c8d67586bdcbc4117 |
| Source note | uspto-grants-2014_02 |