HRID2403127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23558

Didecyldimethylammonium chloride

C22H48ClN

结构：COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1.[Na+]

HCID23681059

Naproxen sodium

C14H13NaO3

PRODUCTS

生成物

结构：CCCCCCCCCC[N+](C)(C)CCCCCCCCCC.COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1

HCID131731749

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The stoichiometric mixture (0.025 mol) of didecyldimethylammonium chloride and naproxen sodium salt were dissolved in distilled water and stirred at room temperature for 1 h. The product was extracted by ethyl acetate and organic phase was separated and then washed with distilled water. Ethyl acetate phase was removed and solvent evaporated. The product, didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate (95% yield), was dried under vacuum. The product is soluble in chloroform, acetone, and DMSO. It lacks miscibility with water and hexane. Thermogravimetric analysis: Tonset5%=156° C., and Tonset=190° C. 1H and 13C NMR (DMSO) were obtained.

WORKUP

后处理

extractionThe product was extracted by ethyl acetate and organic phase
customwas separated
washwashed with distilled water
customEthyl acetate phase was removed
customsolvent evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2968d08bd1cc41e0b2159cacf69410b1
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08802596B2
来源说明: uspto-grants-2014_08

反应 SMILES

[Cl-].[CH2:2]([N+:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])([CH3:14])[CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[CH3:25][C@H:26]([C:39]([O-:41])=[O:40])[C:27]1[CH:32]=[CH:31][C:30]2[CH:33]=[C:34]([O:37][CH3:38])[CH:35]=[CH:36][C:29]=2[CH:28]=1.[Na+]>O>[CH3:38][O:37][C:34]1[CH:33]=[C:30]2[C:29](=[CH:36][CH:35]=1)[CH:28]=[C:27]([C@H:26]([CH3:25])[C:39]([O-:41])=[O:40])[CH:32]=[CH:31]2.[CH2:15]([N+:12]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])([CH3:14])[CH3:13])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]