Sodium Chloride → 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Participants

Reaction Steps

Lidocaine hydrochloride (0.0188 mol) was dissolved in 50 mL methanol and sodium docusate [bis(2-ethylhexyl)sulfosuccinate sodium salt] (0.0188 mol) was dissolved in 50 mL. The two solutions were combined and stirred for two hours, during this time a white precipitate (NaCl) formed. The methanol was removed by rotary evaporation which leaves a white sticky solid. To this solid, 150 mL of chloroform was added. A portion of the product dissolved the chloroform while the byproduct (NaCl) remained as a suspended solid. The NaCl was removed by filtration, and the solvent was removed by rotary evaporation. The product, lidocaine docusate, is a colorless syrup and is dried under high vacuum. 1H and 13C NMR (CDCl3) were obtained.

Provenance & Evidence