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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403149Generated: October 30, 2026

(2S,4R)-tert-butyl 4-(2-chloro-4-fluorophenylthio)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine-1-carboxylate → (2S,4R)-4-(2-chloro-4-fluorophenylthio)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/2403149

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,4R)-tert-butyl 4-(2-chloro-4-fluorophenylthio)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine-1-carboxylateHCID 86692744—
SolventFormic AcidHCID 284—
Product(2S,4R)-4-(2-chloro-4-fluorophenylthio)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamideHCID 8669274399%

Reaction Steps

The reaction of the amide 11A with formic acid yielded (2S,4R)-4-(2-chloro-4-fluorophenylthio)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide as a light yellow viscous oil (99%). MS ISP (m/e): 340.2/342.0 (100/25) [(M+H)]+, 230.2/232.0 (94/40).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08802665B2
Source datasetuspto-grants-2014_08
ORD IDord-978bdaeac6154365bbd88e20796fba5b
Source noteuspto-grants-2014_08