HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-methoxyphenylthio)pyrrolidine-1-carboxylate → (2S,4R)-N-(1-cyanocyclopropyl)-4-(2-methoxyphenylthio)pyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-methoxyphenylthio)pyrrolidine-1-carboxylate | HCID 86692746 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | (2S,4R)-N-(1-cyanocyclopropyl)-4-(2-methoxyphenylthio)pyrrolidine-2-carboxamide | HCID 86692745 | 79% |
Reaction Steps
The reaction of the amide 11C with formic acid yielded (2S,4R)-N-(1-cyanocyclopropyl)-4-(2-methoxyphenylthio)pyrrolidine-2-carboxamide as a light yellow viscous oil (79%). MS ISP (m/e): 318.2 (100) [(M+H)]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802665B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-048a5c9a6e8449ac96e21a2744cfef72 |
| Source note | uspto-grants-2014_08 |