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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403151Generated: October 25, 2026

(2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-1-carboxylate → (2S,4R)-N-(1-cyanocyclopropyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/2403151

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-1-carboxylateHCID 67278971—
SolventFormic AcidHCID 284—
Product(2S,4R)-N-(1-cyanocyclopropyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-2-carboxamideHCID 86692747—

Reaction Steps

The reaction of the amide 11D with formic acid yielded (2S,4R)-N-(1-cyanocyclopropyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-2-carboxamide as a colorless viscous oil (quant.). MS ISP (m/e): 372.1 (94) [(M+H)]+, 262.1 (100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08802665B2
Source datasetuspto-grants-2014_08
ORD IDord-2cce966608fc4c6897ae214078d0f550
Source noteuspto-grants-2014_08