HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylpiperidine → HCID 86762593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylpiperidine | HCID 79081 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | (1-Ethoxycyclopropoxy)trimethylsilane | HCID 2734686 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86762593 | HCID 86762593 | 79% |
Reaction Steps
The reaction of (1-ethoxycyclopropoxy)trimethylsilane 13 and 3-methylpiperidine 14B with trimethylsilylcyanide yielded after column chromatography with a gradient of heptane/ethyl acetate (v:v 4:1) to ethyl acetate as solvent 1-(3-methylpiperidin-1-yl)cyclopropanecarbonitrile as a colorless oil (79%). MS ISP (m/e): 165.2 (100) [(M+H)]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802665B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9312e3c16c7644329ab23b379c01429b |
| Source note | uspto-grants-2014_08 |