HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,4-dibromobutanoate → Methyl 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,4-dibromobutanoate | HCID 296716 | — |
| Reactant | 1-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochloride | HCID 17840002 | — |
| Product | Methyl 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate | HCID 86692753 | 8% |
Reaction Steps
The reaction of methyl 2,4-dibromobutanoate 17 with 1-(2,2,2-trifluoroethyl)piperidin-4-amine hydrochloride 18G yielded methyl 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate as a light brown solid (8%). MS ISP (m/e): 281.1 (100) [(M+H)]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802665B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-959c923e8a75466795a5530835bd4c99 |
| Source note | uspto-grants-2014_08 |