Cyclopentylamine → HCID 4385247, compound

HRID 2403162Notes

Reaction equation

Br[CH:2]([CH2:7][CH2:8]Br)[C:3]([O:5][CH3:6])=[O:4].[CH:10]1([NH2:15])[CH2:14][CH2:13][CH2:12][CH2:11]1>>[CH3:6][O:5][C:3]([CH:2]1[CH2:7][CH2:8][N:15]1[CH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:4]

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 296716Methyl 2,4-dibromobutanoate

Product 1

HCID 4385247HCID 4385247, compoundYield 33%

Procedure

The reaction of methyl 2,4-dibromobutanoate 17 with cyclopentylamine 18I yielded 1-cyclopentyl-azetidine-2-carboxylic acid methyl ester as a light brown solid (33%). MS ISP (m/e): 184.2 (100) [(M+H)]+.

Sources & evidence

ORD record: ord-60623684006841aba24892bc9c90d1c1
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08802665B2

Reaction notes

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