HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-amino-1-piperidinecarboxylate → Ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-amino-1-piperidinecarboxylate | HCID 100867 | — |
| Reactant | Methyl 2,4-dibromobutanoate | HCID 296716 | — |
| Product | Ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate | HCID 86692756 | 50% |
Reaction Steps
The reaction of methyl 2,4-dibromobutanoate 17 with ethyl 4-aminopiperidine-1-carboxylate 18K yielded ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate as a yellow oil (50%). MS ISP (m/e): 271.3 (100) [(M+H)]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802665B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-4fe7b9c194d24cb0a181376ae00c5b93 |
| Source note | uspto-grants-2014_08 |