Formic Acid → HCID 71711234, compound

Participants

Reaction Steps

To a solution of (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(piperazin-1-yl)cyclopropanecarbonyl)pyrrolidine-2-carboxamide (35.4 mg, 70 μmol) and formic acid (5.37 μL, 140 μmol) in methylenehloride (0.7 mL) was added carbonyldiimidazole (23.4 mg, 140 μmol). The reaction was stirred at room temperature over night. The reaction was purified by column chromatography on silica gel using a gradient from methylenechloride to a mixture of methylenechloride/methanol (v:v 19:1) as solvent to yield the title compound as a white solid (25 mg, 67%). MS ISP (m/e): 534.2/536.3 (100/29) [(M+H)]+.

Provenance & Evidence