Water → N-(Bromoacetyl)glycine, ethyl ester

Participants

Reaction Steps

To a mixture of glycine ethyl ester hydrochloride (2.0 g, 14.3 mmol) and K2CO3 (2.1 g, 15.2 mmol) in CH2Cl2 (35 ml) cooled at 0-5° C. bromoacetyl bromide (1.36 ml, 15.6 mmol) was added dropwise. The suspension was stirred at room temperature and after 3 h H2O (20 ml) was added. The phases were separated and the organic one was washed with a saturated solution of NaHCO3 (20 ml) and H2O (20 ml) and dried over Na2SO4. The solvent was evaporated obtaining 39 as white solid (1.2 g, 40%). ESI+MS: calcd for C6H10BrNO3: 224.06; found: 224.0 and 226.0 (MH+).

Provenance & Evidence